In 2015 the Expert Committee on Residues of Veterinary Medicinal Products indicated that a review of Commission Decision (CD) 2002/657/EC is considered necessary. Subsequently, the EURLs were asked to support DG SANTE in this process. In the following years the EURLs carried out surveys among the NRLs on their view on required changes in this Commission Decision, produced first drafts and discussed the drafts during the annual EURL workshops. Finally, DG SANTE prepared a draft revision (SANTE 11188:2018) which was discussed several times at the Working Group on Residues of Veterinary Medicinal Products and was finally voted on at the SC PAFF in the end of 2020. The document is now published in the Official Journal of the European Union as “Commission Implementing Regulation (EU) 2021/808 of 22 March 2021 on the performance of analytical methods for residues of pharmacologically active substances used in food-producing animals and on the interpretation of results as well as on the methods to be used for sampling and repealing Decisions 2002/657/EC and 98/179/EC” and enters into force in June 2021.